연세대, 이화여대 / 진희, 조재호*, 이윤실*
Abstract
Radiation-induced lung injury (RILI), including acute radiation pneumonitis and chronic radiation-induced lung fibrosis, is the most common side effect of radiation therapy. RILI is a complicated process that causes the accumulation, proliferation, and differentiation of fibroblasts and, finally, results in excessive extracellular matrix deposition. Currently, there are no approved treatment options for patients with radiation-induced pulmonary fibrosis (RIPF) partly due to the absence of effective targets. Current research advances include the development of small animal models reflecting modern radiotherapy, an understanding of the molecular basis of RIPF, and the identification of candidate drugs for prevention and treatment. Insights provided by this research have resulted in increased interest in disease progression and prognosis, the development of novel anti-fibrotic agents, and a more targeted approach to the treatment of RIPF.
Affiliations
Hee Jin 1 , Youngjo Yoo 1 , Younghwa Kim 1 , Yeijin Kim 1 , Jaeho Cho 2 , Yun-Sil Lee 1
1 Graduate School of Pharmaceutical Sciences and College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
2 Department of Radiation Oncology, Yonsei University Health System, Seoul 03722, Korea.
편집위원
본 연구논문은 방사선에 의해 유도되는 폐섬유화에 대한 전임상 연구모델에 대한 것으로 치료가능성에 대한 전임상 연구 결과를 제시함.
2020-07-31 15:19:37