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  • [Int Immunopharmacol.] A hydroxyethyl derivative of chrysin exhibits anti-inflammatory activity in dendritic cells and protective effects against dextran sodium salt-induced colitis in mice.

    KAERI / 송하연, 변의백*

  • 출처
    Int Immunopharmacol.
  • 등재일
    2019 Dec
  • 저널이슈번호
    77:105958. doi: 10.1016/j.intimp.2019.105958. Epub 2019 Oct 19.
  • 내용

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    Abstract
    Inflammatory bowel disease (IBD) is a chronic disease that occurs in the intestinal tract. Phyto-ingredients have been evaluated for their ability to protect against IBD because of their anti-inflammatory activities. In our previous study, we identified a novel derivative of chrysin (HE-chrysin) using irradiation technology, which exhibited stronger anti-cancer activity in human colorectal cancer cells than the original chrysin. Here, to determine whether HE-chrysin is a new therapeutic candidate for IBD, we investigated the anti-inflammatory effects of HE-chrysin on bone marrow-derived dendritic cells (BMDCs) and dextran sodium salt (DSS)-induced colitis in mice. HE-chrysin more effectively inhibited BMDC maturation compared to chrysin, as demonstrated by the decreased levels of pro-inflammatory cytokines, surface molecules, antigen-presenting ability, and T cell proliferation/activation in lipopolysaccharide-stimulated BMDCs. These anti-inflammatory effects of HE-chrysin were regulated by mitogen-activated protein kinases and nuclear factor-κB. Furthermore, oral administration of HE-chrysin attenuated DSS-induced colitis symptoms and clinical signs in the mouse model. The protective effects of HE-chrysin treatment against colitis were mediated by decreasing Th1- and Th17-type cytokine levels. These results indicate that HE-chrysin is attractive candidate for IBD therapy.

     


    Author information

    Song HY1, Sik Kim W2, Kim JM3, Bak DH2, Moo Han J1, Lim ST4, Byun EB5.
    1
    Department of Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 56212, Republic of Korea; Department of Biotechnology, College of Life science and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
    2
    Department of Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 56212, Republic of Korea.
    3
    Department of Pathology, College of Medicine, Chungnam National University, Daejeon 301-747, Republic of Korea.
    4
    Department of Biotechnology, College of Life science and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
    5
    Department of Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 56212, Republic of Korea. Electronic address: ebbyun80@kaeri.re.kr.

  • 키워드
    Anti-inflammation; Chrysin derivative; DSS-induced colitis; Dendritic cells; Flavonoids; Inflammatory bowel disease
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