방사선생물학

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  • [Cells.] Plasma Fibrinogen-Like 1 as a Potential Biomarker for Radiation-Induced Liver Injury.

    KIRAMS / 한나경, 정명구, 박수철*, 이해준*

  • 출처
    Cells.
  • 등재일
    2019 Sep 6
  • 저널이슈번호
    8(9). pii: E1042. doi: 10.3390/cells8091042.
  • 내용

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    Abstract
    Liver damage upon exposure to ionizing radiation, whether accidental or because of therapy can contribute to liver dysfunction. Currently, radiation therapy is used for various cancers including hepatocellular carcinoma; however, the treatment dose is limited by poor liver tolerance to radiation. Furthermore, reliable biomarkers to predict liver damage and associated side-effects are unavailable. Here, we investigated fibrinogen-like 1 (FGL1)-expression in the liver and plasma after radiation exposure. We found that 30 Gy of liver irradiation (IR) induced cell death including apoptosis, necrosis, and autophagy, with fibrotic changes in the liver occurring during the acute and subacute phase in mice. Moreover, FGL1 expression pattern in the liver following IR was associated with liver damage represented by injury-related proteins and oxidative stress markers. We confirmed the association between FGL1 expression and hepatocellular injury by exposing human hepatocytes to radiation. To determine its suitability, as a potential biomarker for radiation-induced liver injury, we measured FGL1 in the liver tissue and the plasma of mice following total body irradiation (TBI) or liver IR. In TBI, FGL1 showed the highest elevation in the liver compared to other major internal organs including the heart, lung, kidney, and intestine. Notably, plasma FGL1 showed good correlation with radiation dose by liver IR. Our data revealed that FGL1 upregulation indicates hepatocellular injury in response to IR. These results suggest that plasma FGL1 may represent a potential biomarker for acute and subacute radiation exposure to the liver.

     


    Author information

    Han NK1, Jung MG2, Jeong YJ3, Son Y4,5, Han SC6, Park S7, Lim YB8, Lee YJ9, Kim SH10, Park SC11, Lee HJ12.
    1
    Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul 01812, Korea. gmxvz@hanmail.net.
    2
    Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul 01812, Korea. xnaktm@daum.net.
    3
    Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul 01812, Korea. whyj0914@kirams.re.kr.
    4
    Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul 01812, Korea. sonyh@kribb.re.kr.
    5
    Primate Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeonbuk 56216, Korea. sonyh@kribb.re.kr.
    6
    Division of Medical Radiation Equipment, Korea Institute of Radiological & Medical Sciences, Seoul 01812, Korea. calmhan@kirams.re.kr.
    7
    Division of Medical Radiation Equipment, Korea Institute of Radiological & Medical Sciences, Seoul 01812, Korea. swpark@kirams.re.kr.
    8
    Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul 01812, Korea. yblim@kirams.re.kr.
    9
    Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul 01812, Korea. yjlee8@kirams.re.kr.
    10
    College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea. shokim@chonnam.ac.kr.
    11
    Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea. hepapark@kirams.re.kr.
    12
    Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, Seoul 01812, Korea. hjlee@kirams.re.kr.

  • 키워드
    FGL1; biomarker; liver; plasma; radiation toxicity
  • 편집위원

    HCC 방사선치료 과정에서의 간손상은 간기능 손실의 원인이 되지만, 적절한 biomarker가 발굴되지 않은 상태다. 본 연구에서는 방사선 조사에 따른 fibrinogen-like 1(FGL1)의 발현 양상이 간 손상과 관련 있음을 증명함으로써, FGL1이 간조직에서 acute/subacute radiation exposure의 biomarker가 될 수 있음을 밝혔다.

    2019-10-30 17:16:59

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