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  • [Anticancer Res.] ARID3A Positivity Correlated With Favorable Prognosis in Patients With Residual Rectal Cancer After Neoadjuvant Chemoradiotherapy.

    경북의대 / 윤길석, 박지영, 서안나*

  • 출처
    Anticancer Res.
  • 등재일
    2019 Jun
  • 저널이슈번호
    39(6):2845-2853. doi: 10.21873/anticanres.13413.
  • 내용

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    Abstract
    BACKGROUND/AIM:
    Recent studies have shown a marked increase of AT-rich interactive domain 3A (ARID3A) in colon cancer tissue compared to normal colon mucosa. However, the role of ARID3A has not yet been determined in rectal cancer. We, therefore, investigated the clinical relevance of ARID3A expression in patients with residual rectal cancer after neoadjuvant chemoradiotherapy (NACRT).

    MATERIALS AND METHODS:
    One hundred thirty-four patients who underwent surgical resection for residual rectal cancer after NACRT were analyzed. ARID3A expression was evaluated using immunohistochemistry on whole-tissue sections. KRAS exon 2 (codons 12 and 13) and BRAF V600E mutation status were determined using polymerase chain reaction.

    RESULTS:
    ARID3A positivity was found in 91 cases (64.5%), and it correlated with absence of perineural invasion (p=0.031), longer disease-free survival (DFS) (p=0.048) and cancer-specific survival (CSS) (p=0.006). However, ARID3A positivity was not correlated with KRAS (p=0.231) or BRAF mutation status (p=0.577). In multivariate analysis, ARID3A positivity was independently associated with a favorable CSS (p=0.035), but not DFS (p=0.051).

    CONCLUSION:
    ARID3A positivity can predict favorable prognosis in patients with residual rectal cancer after NACRT.

     


    Author information

    Yoon G1, Park JY1, Kim HJ2, Choi GS2, Kim JG3, Kang BW3, Kang MK4, Seo AN5.
    1
    Department of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.
    2
    Department of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.
    3
    Department of Oncology/Hematology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.
    4
    Department of Radiation Oncology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.
    5
    Department of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea san_0729@naver.com.

  • 키워드
    AT-rich interactive domain 3A; Rectal cancer; neoadjuvant chemoradiotherapy; prognostic marker
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