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  • [Sci Rep.] Radiosensitization by Marine Sponge Agelas sp. Extracts in Hepatocellular Carcinoma Cells with Autophagy Induction.

    성균관의대 / 최창훈, 박희철*

  • 출처
    Sci Rep.
  • 등재일
    2018 Apr 20
  • 저널이슈번호
    8(1):6317. doi: 10.1038/s41598-018-24745-w.
  • 내용

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    Abstract
    Although radiation therapy is an effective treatment modality in many cancers, there is an urgent need to develop therapeutic drugs capable of overcoming radioresistance or minimizing normal tissue toxicity. A wide variety of marine-derived bioactive compounds have been screened for anti-cancer drug discovery, but little is known regarding radiation therapy applications. In this study, six different extracts of marine sponges collected from the Micronesian sea were screened for anti-cancer and radiosensitizing activity. Two extracts derived from Agelas sponges collected off the coast of Kosrae and Chuuk, the Federated States of Micronesia significantly decreased clonogenic survival of hepatocellular carcinoma (HCC) cells after exposure to ionizing radiation (IR). The Agelas extracts augmented IR-induced apoptosis and accumulation of reactive oxygen species (ROS). Endoplasmic reticulum (ER) stress was increased via unfolded protein response stimulation, which induced autophagy. N-acetylcysteine, a ROS scavenger, diminished ER stress and autophagy induction effects. This result indicated that Agelas extracts may sensitize HCC cells to IR via ROS overproduction in vitro. Our findings suggest that the Agelas sp. may have potential utility in radiosensitizer development.

     


    Author information

    Choi C1, Son A1, Lee HS2, Lee YJ2, Park HC3,4.
    1
    Department of Radiation Oncology, Samsung Medical Center, Seoul, 06351, South Korea.
    2
    Marine Natural Product Chemistry Laboratory, Korea Institute of Ocean Science, and Technology, Ansan, 426-744, South Korea.
    3
    Department of Radiation Oncology, Samsung Medical Center, Seoul, 06351, South Korea. hee.ro.park@samsung.com.
    4
    Sungkyunkwan University School of Medicine, Seoul, 06351, South Korea. hee.ro.park@samsung.com.

  • 편집위원

    대부분 방사선조사에 의해 발생하는 세포사는 apoptosis과정을 거치는데 발생하는데 maringe sponge를 이용하여 anticancer effect를 확인하는 개념과 apoptosis와 다른 autophagy를 통해서 그 역할이 구현되는 것이 흥미로운 점이었습니다.

    2018-05-09 11:02:39

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