글로벌 연구동향
의학물리학
- 2022년 07월호
[Front Vet Sci.] Development of Total Lymphoid Irradiation (TLI)-Dedicated Shielding and Image-Guided System and Dose Evaluation Using 3D-Printed Rat Phantom연세의대 / 최동혁, 안소현*, 박광우*
- 출처
- Front Vet Sci.
- 등재일
- 2022 May 18
- 저널이슈번호
- 9:832272. doi: 10.3389/fvets.2022.832272. eCollection 2022.
- 내용
Abstract
Purpose: The purpose of this study is to propose a technique for delivering accurate doses in an image-guided system by developing an experimental setup optimized for total lymphoid irradiation (TLI) in rat lung transplantation.Materials and methods: In this study, a position-controlled shielding system was developed, and the dose was quantitatively evaluated using a 3D rat phantom and Gafchromic EBT3 film. In addition, we made our own image-guided system that allows the position of the rat and the shielding system to be confirmed during TLI.
Results: As a result of using the position-controlled shielding system, it was found that the doses to the head and lungs were reduced by 93.1 and 87.4%, respectively, of the prescribed doses. In addition, it was shown that the position of the shielding system can be easily confirmed by using the image guidance system.
Conclusion: A shielding apparatus that can control dose delivery according to the size of the rat can optimize the dose for TLI in rat lung transplantation.
Affiliations
Dong Hyeok Choi 1 , So Hyun Ahn 2 , Kwangwoo Park 3 , Sang Hyun Choi 4 , Jin Sung Kim 1 2
1 Department of Medicine, Yonsei University College of Medicine, Seoul, South Korea.
2 Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.
3 Department of Radiation Oncology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, South Korea.
4 Research Team of Radiological Physics and Engineering, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea.
- 키워드
- 3D-printed phantom; image-guided radiotherapy; in vivo dosimetry; position-controlled shielding system; rat; total lymphoid irradiation.
- 연구소개
- 본 논문은 쥐의 폐 이식을 시행할 때 TLI에 최적화된 실험 장치를 개발하여 image-guided radiation therapy (IGRT) 시스템에서 정확한 선량을 전달하는 기술을 제시합니다. 우리 연구는 위치 제어 차폐 시스템을 개발하고 3D 쥐 팬텀과 EBT3 필름을 사용하여 선량을 정량적으로 평가했습니다. 또한 IGRT 시스템을 통해 차폐 장치의 위치를 쉽게 식별할 수 있음을 보여줍니다. 쥐 폐 이식에서 TLI에 최적화된 실험 설정이 선량을 전달하는 새롭고, 효과적인 방법이기 때문에 이 논문은 여러 독자들에게 흥미로울 것이라고 믿습니다.
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