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  • [Med Phys.] Study on the RBE estimation for carbon beam scanning irradiation using a solid-state microdosimeter.고체 선량계를 이용한 탄소 중입자 스캐닝 방사선빔의 생물학적 효과 연구

    KIRAMS / 한수림, 김금배*, 유승순*

  • 출처
    Med Phys.
  • 등재일
    2020 Feb
  • 저널이슈번호
    47(2):363-370. doi: 10.1002/mp.13924. Epub 2019 Dec 2.
  • 내용

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    Abstract
    PURPOSE:
    The purpose of this study was to study the field size effect on the estimated Relative Biological Effectiveness (RBE) for carbon scanning beam irradiation.

    METHODS:
    A silicon-on-insulator (SOI) microdosimeter system developed by the Centre for Medical Radiation Physics, University of Wollongong, Australia, was used for lineal-energy measurements (microdosimetric quantity). The RBE values were derived based on the modified microdosimetric kinetic model (MKM) at different depths in a water phantom in the scanning carbon beam for various scanned areas.

    RESULTS:
    Our study shows that the difference in RBE values derived from the SOI microdosimeter measurements with the MKM model and from the Treatment Planning System (TPS). The difference of the RBE values is within 6.5 % at the peak point of the spread-out Bragg Peak (SOBP) region. Compared to the spot-beam, RBE values obtained in the scanned-beam with a larger scanned area of 1.0 × 1.0 cm2 have better agreement with which estimated by the TPS.

    CONCLUSIONS:
    This study shows the possibility of using the SOI microdosimeter system as a quality assurance (QA) tool for RBE evaluation in carbon-pencil beam scanning radiotherapy.

     


    Author information

    Han S1, Yoo SH1, Shin JI1, Kim EH1, Jung WG1, Kim KB2, Matsumura A3, Kanai T3, Tran LT4, Chartier L4, James B4, Rosenfeld AB4.
    1
    Division of Heavy-Ion Clinical Research, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
    2
    Department of Radiation Oncology, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
    3
    Gunma Heavy Ion Medical Center, Gunma, Japan.
    4
    Center for Medical Radiation Physics, University of Wollongong, Wollongong, Australia.

  • 키워드
    LET measurement; RBE prediction; SOI detector; carbon scanning beam
  • 편집위원

    탄소 중입자 치료에서 RBE아직까지 중요한 이슈이며 Solid-State Microdosimeter로 시도 했다는 점이 흥미로움

    2020-04-01 16:29:32

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