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  • [Med Phys.] Deep feature classification of angiomyolipoma without visible fat and renal cell carcinoma in abdominal contrast-enhanced CT images with texture image patches and hand-crafted feature concatenation.

    KAIST / 이한상, 김준모*

  • 출처
    Med Phys.
  • 등재일
    2018 Feb 23.
  • 저널이슈번호
    doi: 10.1002/mp.12828. [Epub ahead of;
  • 내용

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    Abstract
    PURPOSE:
    To develop an automatic deep feature classification (DFC) method for distinguishing benign angiomyolipoma without visible fat (AMLwvf) from malignant clear cell renal cell carcinoma (ccRCC) from abdominal contrast-enhanced computer tomography (CE CT) images.

    METHODS:
    A dataset including 80 abdominal CT images of 39 AMLwvf and 41 ccRCC patients was used. We proposed a DFC method for differentiating the small renal masses (SRM) into AMLwvf and ccRCC using the combination of hand-crafted and deep features, and machine learning classifiers. First, 71-dimensional hand-crafted features (HCF) of texture and shape were extracted from the SRM contours. Second, 1000-4000-dimensional deep features (DF) were extracted from the ImageNet pretrained deep learning model with the SRM image patches. In DF extraction, we proposed the texture image patches (TIP) to emphasize the texture information inside the mass in DFs and reduce the mass size variability. Finally, the two features were concatenated and the random forest (RF) classifier was trained on these concatenated features to classify the types of SRMs. The proposed method was tested on our dataset using leave-one-out cross-validation and evaluated using accuracy, sensitivity, specificity, positive predictive values (PPV), negative predictive values (NPV), and area under receiver operating characteristics curve (AUC). In experiments, the combinations of four deep learning models, AlexNet, VGGNet, GoogleNet, and ResNet, and four input image patches, including original, masked, mass-size, and texture image patches, were compared and analyzed.

    RESULTS:
    In qualitative evaluation, we observed the change in feature distributions between the proposed and comparative methods using tSNE method. In quantitative evaluation, we evaluated and compared the classification results, and observed that (a) the proposed HCF + DF outperformed HCF-only and DF-only, (b) AlexNet showed generally the best performances among the CNN models, and (c) the proposed TIPs not only achieved the competitive performances among the input patches, but also steady performance regardless of CNN models. As a result, the proposed method achieved the accuracy of 76.6 ± 1.4% for the proposed HCF + DF with AlexNet and TIPs, which improved the accuracy by 6.6%p and 8.3%p compared to HCF-only and DF-only, respectively.

    CONCLUSIONS:
    The proposed shape features and TIPs improved the HCFs and DFs, respectively, and the feature concatenation further enhanced the quality of features for differentiating AMLwvf from ccRCC in abdominal CE CT images.

     


    Author information

    Lee H1, Hong H2, Kim J1, Jung DC3.
    1
    School of Electrical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Korea.
    2
    Department of Software Convergence, College of Interdisciplinary Studies for Emerging Industries, Seoul Women's University, 621 Hwarang-ro, Nowon-gu, Seoul, 01797, Korea.
    3
    Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.

  • 키워드
    angiomyolipoma without visible fat (AMLwvf); clear cell renal cell carcinoma (ccRCC); computed tomography (CT); computer-aided diagnosis (CAD); deep feature classification
  • 편집위원

    CT영상에서 구분이 쉽지 않은 renal cell carcinoma에서도 deep learning을 통해 구분을 할 수 있었고, hand crafted feature과 deep feature를 결합하는 방법을 통해 정확도가 7~8% 향상된 결과를 얻었다. 앞으로 더욱 발전하면 사람을 능가하는 날이 곧 올것인가?

    2018-04-17 11:06:41

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