글로벌 연구동향
핵의학
- 2023년 08월호
[Clin Nucl Med .] Prediction of Malignant Thyroid Nodules Using 18 F-FDG PET/CT-Based Radiomics Features in Thyroid Incidentalomas
18-FDG PET/CT 기반의 방사선학적 특징을 이용한 갑상선 우연종의 악성도 예측부산대병원 / 고우성, 김성장*
- 출처
- Clin Nucl Med .
- 등재일
- 2023 Jun 1
- 저널이슈번호
- 48(6):497-504.
- 내용
Abstract
Objective: The purpose of the current study was to evaluate the diagnostic performances of 18 F-FDG PET/CT-based radiomics features for prediction of malignant thyroid nodules (TNs) in thyroid incidentaloma (TI).Methods: PubMed, Cochrane database, and EMBASE database, from the earliest available date of indexing through December 31, 2022, were searched for studies evaluating diagnostic performance of 18 F-FDG PET/CT-based radiomics features for prediction of malignant TNs in TI. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LRs; positive and negative LRs), and estimated pooled area under the curve.
Results: Across 5 studies (518 patients), the pooled sensitivity of 18 F-FDG PET/CT was 0.77 (95% confidence interval [CI], 0.67-0.84), and a pooled specificity was 0.67. Likelihood ratio syntheses gave an overall positive LR of 2.3 (95% CI, 1.5-3.6) and negative LR of 0.35 (95% CI, 0.26-0.47). The pooled diagnostic odds ratio was 7 (95% CI, 4-12). The pooled area under the curve of fixed effects was 0.763 (95% CI, 0.736-0.791), and that of random effects was 0.763 (95% CI, 0.721-0.805).
Conclusion: 18 F-FDG PET/CT-based radiomics features showed a good diagnostic performance for prediction of malignant TNs in TI.
Affiliation
Woo Seog Ko 1, Seong-Jang Kim
1From the Department of Internal Medicine, Pusan National University Hospital, Busan.
- 덧글달기
- 이전글 [Nucl Med Commun .] Brain FDG PET for visualizing the relation between impaired lung function and cognitive decline in lung cancer: a preliminary study
- 다음글 [Front Oncol .] Metabolic bulk volume predicts survival in a homogeneous cohort of stage II/III diffuse large B-cell lymphoma patients undergoing R-CHOP treatment
편집위원
FDG PET/CT에서 우연히 발견된 갑상선결절을 radiomics 기법을 이용하여 악성갑상선 결절을 예측하는 meta-analysis연구임. 해당 연구에서는 FDG PET/CT 기반 radiomics를 적용하며 비교적 악성 갑상선결절을 잘 예측할 수 있음을 보여줌. 이는 FDG PET/CT를 시행하는 핵의학임상가 및 핵의학영상분석 연구자들에게 관심을 끌 흥미로운 연구로 생각됨.
덧글달기닫기2023-08-08 14:17:53
등록
편집위원2
PET/CT에서 갑상선의 우연종이 발견되는 경우가 드물진 않은데, 실제 임상에서 어렵지 않게 악성화 가능성에 대한 기본 자료로 활용 가능할 것으로 기대됨.
덧글달기닫기2023-08-08 14:21:44
등록