글로벌 연구동향
핵의학
- 2023년 02월호
[Clin Nucl Med.] Diverse Patterns and Clinical Significance of 11C-Methionine PET in Dysembryoplastic Neuroepithelial Tumors서울의대 / 김중환, 강연구, 팽진철*, 피지훈*
- 출처
- Clin Nucl Med.
- 등재일
- 2022 Dec 1
- 저널이슈번호
- 47(12):1040-1047. doi: 10.1097/RLU.0000000000004400.
- 내용
Abstract
Purpose: Dysembryoplastic neuroepithelial tumors (DNETs) are slow-growing epilepsy-associated tumors. Low or normal 11C-methionine (MET) PET uptake helps to differentiate DNETs from other low-grade gliomas. However, diverse MET-PET uptake in DNETs has been observed. The aim of this study is to measure the clinical significance and prognostic value of MET-PET in DNET management.Patients and methods: Retrospective review of 26 DNET patients was done. Clinical characteristics, radiologic findings, and visual and quantitative MET-PET results were analyzed. PET uptake was calculated as the tumor-to-homotopic mirror ratio (TNRm) and tumor-to-contralateral cortex ratio (TNRc). The clinical activity of the tumors at the time of PET was classified into active and quiescent groups. The surgical outcome was defined as a composite of 2 different aspects: tumor progression and/or clinical events such as seizure recurrence or tumor bleeding.
Results: Twenty-seven MET-PET examinations (20 initial MET-PET and 7 MET-PET during follow-up) were included. Clinically active tumors at the time of PET presented significantly higher values of TNRm and TNRc than quiescent tumors. High MET-PET uptake by visual grading, TNRm ≥ 1.90, and TNRc ≥ 1.85 exhibited poor prognosis for event-free survival.
Conclusions: MET-PET uptake correlates well with the clinical behavior of DNETs at the time of PET examination. Moreover, High MET-PET uptake is closely related to seizure recurrence if tumors are not entirely resected. Efforts to achieve gross total resection should be made for DNETs with high MET-PET uptake.
Affiliations
Joo Whan Kim 1, Yeon-Koo Kang 2, Jin Chul Paeng 2, Seung-Ki Kim 1, Byung Chan Lim 3, Ki Joong Kim 3, Ji Hoon Phi 1
1From the Division of Pediatric Neurosurgery.
2Department of Nuclear Medicine.
3Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, South Korea.
- 덧글달기
편집위원
Dysembryoplastic neuroepithelial tumors (DNETs) 에서 C-11 methionine PET의영상결과로 임상적 의미를 검토하고자 하였음. 연구결과 C-11 methionine 축적이 높은 종양은 완전히 제거되지 않으면, 뇌전증의 발생이 높다는 것을 보여줌. C-11 methionine섭취가 높은 DNETs은 수술시 완전절제를 위한 노력이 필요함을 보여준 임상연구임. 해당 연구결과는 종양신경외과 및 핵의학 전문가의 관심을 끌 흥미로운 연구로 생각됨.
덧글달기닫기2023-02-06 15:46:32
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