글로벌 연구동향
핵의학
- 2022년 02월호
[Exp Cell Res.] Engineered extracellular vesicle mimetics from macrophage promotes hair growth in mice and promotes human hair follicle growth경북대 / Ramya Lakshmi Rajendran, 안병철*
- 출처
- Exp Cell Res.
- 등재일
- 2021 Dec 1
- 저널이슈번호
- 409(1):112887. doi: 10.1016/j.yexcr.2021.112887. Epub 2021 Oct 19.
- 내용
Abstract
Recent studies clearly show that cell-derived extracellular vesicles (EVs, including exosomes) can promote hair growth. However, large-scale production of EVs remains a big hurdle. Recently, extracellular vesicle mimetics (EMs) engineered by extrusion through various membranes are emerging as a complementary approach for large-scale production. In this study, to investigate their ability to induce hair growth, we generated macrophage-engineered EMs (MAC-EMs) that activated the human dermal papilla (DP) cells in vitro. MAC-EMs intradermally injected into the skin of C57BL/6 mice were retained for up to 72 h. Microscopy imaging revealed that MAC-EMs were predominately internalized into hair follicles. The MAC-EMs treatment induced hair regrowth in mice and hair shaft elongation in a human hair follicle, suggesting the potential of MAC-EMs as an alternative to EVs to overcome clinical limitation.Affiliations
Ramya Lakshmi Rajendran 1 , Prakash Gangadaran 2 , Mi Hee Kwack 3 , Ji Min Oh 1 , Chae Moon Hong 4 , Arunnehru Gopal 1 , Young Kwan Sung 3 , Jaetae Lee 5 , Byeong-Cheol Ahn 6
1 Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
2 Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
3 BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; Department of Immunology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
4 Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea.
5 Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea.
6 Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea. Electronic address: abc2000@knu.ac.kr.
- 키워드
- Extracellular vesicle mimetics; Hair growth; Macrophage; Mice and human hair follicle.
- 연구소개
- 대식세포에서 유래된 세포외소포는 모발재생에 효과가 있으나, 대량생산에는 문제점이 있다. 이 연구는 대식세포로부터 세포외소포 유사체를 공학적으로 생산하여 이 유사체가 모발재생에 어떠한 효과를 가지는지를 평가하였다. 해당 세포외소포 유사체는 인체모낭조직절편에서도 모발성장을 촉진하였고, 동물모델에서도 모발의 성장을 빨라지게 하는 효과를 보여주었다.
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