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핵의학
- 2021년 10월호
[Cancers (Basel).] Prognostic Role of Pre-Treatment [ 18 F]FDG PET/CT in Patients with Anaplastic Thyroid Cancer연세의대 / 김현정, 장항석*, 유영훈*
- 출처
- Cancers (Basel).
- 등재일
- 2021 Aug 23
- 저널이슈번호
- 13(16):4228. doi: 10.3390/cancers13164228.
- 내용
Abstract
Anaplastic thyroid carcinoma (ATC) is a rare but highly lethal disease. Therefore, its diagnosis at an early stage and a rapid and accurate establishment of a proper treatment strategy is warranted. Tumor glycolysis assessed by 18fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET)/computed tomography (CT) is predictive of many cancers despite its limited proven applicability to ATC. We investigated the prognostic capability of [18F]FDG PET/CT in patients with ATC. Forty patients with ATC were subjected to [18F]FDG PET/CT for pre-treatment evaluation. The tumor size and stage, overall survival (OS), and PET parameters, including the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were analyzed. The 1-year OS rate was 17.5% with a mean life expectancy of 7.1 months. Distant metastasis was detected solely using PET/CT in 37.5% of cases. High SUVmax, MTV, and TLG were significantly associated with poor prognosis (p < 0.001, p = 0.002, and p < 0.001, respectively). A significant difference (p < 0.001) was observed in OS between patients with a high and low tumor SUVmax. Glucose metabolism assessed by [18F]FDG PET/CT was significantly associated with the OS of patients with ATC. PET-derived parameters such as SUVmax, MTV, and TLG are useful prognostic biomarkers for ATC.Affiliations
Hyun Jeong Kim 1 , Hang-Seok Chang 2 , Young Hoon Ryu 3
1 Department of Nuclear Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin 16995, Korea.
2 Department of Surgery, Thyroid Cancer Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea.
3 Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea.
- 키워드
- [18F]FDG PET/CT; anaplastic thyroid carcinoma; glycolysis; prognosis.
- 덧글달기
- 이전글 [Br J Surg.] Metabolic activity by FDG-PET/CT after neoadjuvant chemotherapy in borderline resectable and locally advanced pancreatic cancer and association with survival
- 다음글 [Clin Nucl Med.] Performance Evaluation of a Deep Learning System for Differential Diagnosis of Lung Cancer With Conventional CT and FDG PET/CT Using Transfer Learning and Metadata.
편집위원
18F-FDG PET으로 구한 SUVmax, MTV, 등의 metabolic parameters가 anaplastic thyroid cancer 환자의 예후를 예측할 수 있는지를 알아본 임상연구 논문임. 이번 연구에서 FDG PET에서 구한 SUVmax가 overall survival을 예측할 수 있음을 확인하였음. Anaplastic thyroid cancer에서 18F-FDG PET의 예후인자로서의 가치를 밝힌 연구로 핵의학 임상가 및 갑상선암관련 임상의사에게 관심을 끌 연구로 생각됨.
덧글달기닫기2021-10-05 15:51:56
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