글로벌 연구동향
핵의학
- 2020년 05월호
[Neurobiol Aging.] Distinguishing between dementia with Lewy bodies and Alzheimer's disease using metabolic patterns.연세의대 / 예병석, 윤미진*
- 출처
- Neurobiol Aging.
- 등재일
- 2020 Mar
- 저널이슈번호
- 87:11-17. doi: 10.1016/j.neurobiolaging.2019.10.020. Epub 2019 Nov 5.
- 내용
Abstract
Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the 2 most common causes of dementia. We compared the regional metabolism on 18F-fluorodeoxyglucose positron emission tomography (PET) among 21 control subjects and cognitively impaired patients due to DLB (N = 63) and AD (N = 38). All participants underwent 18F-Florbetaben (FBB) PET, and all DLB patients had abnormality on dopamine transporter PET. Both the FBB-positive DLB (N = 38) and FBB-negative DLB (N = 25) groups had increased metabolism in the bilateral central cerebellum, posterior putamen, and somatomotor cortices compared with the control and AD groups. Compared with the control group, the DLB and AD groups commonly exhibited hypometabolism in the bilateral lateral temporal, temporo-parietal junction, posterior cingulate, and precuneus cortices. Both DLB groups had additional hypometabolism in the bilateral thalami and dorsolateral prefrontal cortices, whereas the AD group did in the bilateral entorhinal cortices and hippocampi. Our results suggest that hypermetabolism in the somatomotor cortex, posterior putamen, or central cerebellum could be a useful imaging biomarker for detecting DLB patients, while entorhinal/hippocampal hypometabolism could be a specific biomarker for AD.
Author informationYe BS1, Lee S2, Yoo H1, Chung SJ1, Lee YH1, Choi Y2, Lee PH1, Sohn YH1, Yun M3.
1
Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
2
Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, South Korea.
3
Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: YUNMIJIN@yuhs.ac.
- 키워드
- Alzheimer`s disease; Amyloid-β; Dementia with Lewy bodies; Fluorodeoxyglucose positron emission tomography; Metabolism
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