핵의학

본문글자크기
  • [J Clin Neurol.] Clinical Usefulness of 18F-FC119S Positron-Emission Tomography as an Auxiliary Diagnostic Method for Dementia: An Open-Label, Single-Dose, Evaluator-Blind Clinical Trial.

    KIRAMS / 이인기, 나혜리, 하정호*, 임상무*

  • 출처
    J Clin Neurol.
  • 등재일
    2020 Jan
  • 저널이슈번호
    16(1):131-139. doi: 10.3988/jcn.2020.16.1.131.
  • 내용

    바로가기  >

    Abstract
    BACKGROUND AND PURPOSE:
    The aim of this study was to determine the diagnostic performance and safety of a new ¹⁸F-labeled amyloid tracer, ¹⁸F-FC119S.

    METHODS:
    This study prospectively recruited 105 participants, comprising 53 with Alzheimer's disease (AD) patients, 16 patients with dementia other than AD (non-AD), and 36 healthy controls (HCs). In the first screening visit, the Seoul Neuropsychological Screening Battery cognitive function test was given to the dementia group, while HC subjects completed the Korean version of the Mini Mental State Examination. Individuals underwent ¹⁸F-FC119S PET, ¹⁸F-fluorodeoxyglucose (FDG) PET, and brain MRI. The diagnostic performance of ¹⁸F-FC119S PET for AD was compared to a historical control (comprising previously reported and currently used amyloid-beta PET agents), ¹⁸F-FDG PET, and MRI. The standardized uptake value (SUV) ratio (ratio of the cerebral cortical SUV to the cerebellar SUV) was measured for each PET data set to provide semiquantitative analysis. All adverse effects during the clinical trial periods were monitored.

    RESULTS:
    Visual assessments of the ¹⁸F-FC119S PET data revealed a sensitivity of 92% and a specificity of 84% in detecting AD. ¹⁸F-FC119S PET demonstrated equivalent or better diagnostic performance for AD detection than the historical control, ¹⁸F-FDG PET (sensitivity of 80.0% and specificity of 76.0%), and MRI (sensitivity of 98.0% and specificity of 50.0%). The SUV ratios differed significantly between AD patients and the other groups, at 1.44±0.17 (mean±SD) for AD, 1.24±0.09 for non-AD, and 1.21±0.08 for HC. No clinically significant adverse effects occurred during the trial periods.

    CONCLUSIONS:
    ¹⁸F-FC119S PET provides high sensitivity and specificity in detecting AD and therefore may be considered a useful diagnostic tool for AD.

     


    Author information

    Lee I#1, Na HR#2, Byun BH1, Lim I1, Kim BI1, Choi CW1, Ko IO3, Lee KC3, Kim KM3, Park SY4, Kim YK5, Lee JY6, Bu SH7, Kim JH7, Kil HS8, Park C8, Chi DY8,9, Ha JH10, Lim SM11.
    1
    Department of Nuclear Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
    2
    Department of Neurology, Bobath Memorial Hospital, Seongnam, Korea.
    3
    Division of Applied RI, Research Institute of Radiological & Medical Sciences, Korea Institutes of Radiological & Medical Sciences, Seoul, Korea.
    4
    Department of Neurology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
    5
    Department of Nuclear Medicine, Seoul National University College of Medicine & SMG-SNU Boramae Medical Center, Seoul, Korea.
    6
    Department of Psychiatry and Behavioural Science, College of Medicine, Seoul National University, Boramae Hospital, Seoul, Korea.
    7
    Department of Neurology, Seoul Bukbu Hospital, Seoul, Korea.
    8
    Research Institute of Labelling, FutureChem Co., Ltd, Seoul, Korea.
    9
    Department of Chemistry, Sogang University, Seoul, Korea.
    10
    Department of Neurology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea. jhha@kirams.re.kr.
    11
    Department of Nuclear Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea. smlim328@kirams.re.kr.
    #
    Contributed equally

  • 키워드
    Alzheimer`s disease; amyloid beta-peptides; clinical trial; dementia; positron-emission tomography; ¹⁸F-FC119S
  • 덧글달기
    덧글달기
       IP : 3.94.150.98

    등록