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  • [Eur J Nucl Med Mol Imaging.] 백색질과 회백질의 타우PET분포차이Differences in gray and white matter 18F-THK5351 uptake between behavioral-variant frontotemporal dementia and other dementias.

    울산의대 / 손혜주, 오정수, 김재승*

  • 출처
    Eur J Nucl Med Mol Imaging.
  • 등재일
    2019 Feb
  • 저널이슈번호
    46(2):357-366. doi: 10.1007/s00259-018-4125-x. Epub 2018 Aug 14.
  • 내용

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    Abstract
    PURPOSE:
    We investigated the regional distribution of 18F-THK5351 uptake in gray (GM) and white matter (WM) in patients with behavioral-variant frontotemporal dementia (bvFTD) and compared it with that in patients with Alzheimer's disease (AD) or semantic dementia (SD).

    METHODS:
    18F-THK-5351 positron emission tomography (PET), 18F-florbetaben PET, magnetic resonance imaging, and neuropsychological testing were performed in 103 subjects including 30, 24, 9, and 8 patients with mild cognitive impairment, AD, bvFTD, and SD, respectively, and 32 normal subjects. Standardized uptake value ratios (SUVRs) of 18F-THK-5351 PET images were measured from six GM and WM regions using cerebellar GM as reference. GM and WM SUVRs and WM/GM ratios, the relationship between GM SUVR and WM/GM ratio, and correlation between SUVR and cognitive function were compared.

    RESULTS:
    In AD, both parietal GM (p < 0.001) and WM (p < 0.001) SUVRs were higher than in bvFTD. In AD and SD, the WM/GM ratio decreased as the GM SUVR increased, regardless of lobar region. In AD, memory function correlated with parietal GM (ρ = -0.74, p < 0.001) and WM (ρ = -0.53, p < 0.001) SUVR. In SD, language function correlated with temporal GM SUVR (ρ = -0.69, p = 0.006). The frontal WM SUVR was higher in bvFTD than in AD (p = 0.003) or SD (p = 0.017). The frontal WM/GM ratio was higher in bvFTD than in AD (p < 0.001). In bvFTD, the WM/GM ratio increased more prominently than the GM SUVR only in the frontal lobe (R2 = 0.026). In bvFTD, executive function correlated with frontal WM SUVR (ρ = -0.64, p = 0.014).

    CONCLUSIONS:
    Frontal WM 18F-THK5351 uptake was higher in bvFTD than in other dementias. The increase in frontal WM uptake was greater than the increase in GM uptake and correlated with executive function. This suggests that frontal lobe WM 18F-THK5351 uptake reflects neuropathological differences between bvFTD and other dementias.

     


    Author information

    Son HJ1, Oh JS1, Roh JH2, Seo SW3, Oh M1, Lee SJ1, Oh SJ1, Kim JS4.
    1
    Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
    2
    Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
    3
    Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro Gangnam-gu, Seoul, 06351, Republic of Korea.
    4
    Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea. jaeskim@amc.seoul.kr.

  • 키워드
    18F-THK-5351; Behavioral-variant frontotemporal dementia; PET; Tau; White matter
  • 편집위원

    치매환자에서 Tau 영상 PET tracer인 18F-THK5351의 임상적 의미를 밝힌 임상연구로 Tau PET 영상의 가치를 높이고 임상적 활용도를 높일 수 있는 연구로 치매와 관련된 신경 핵의학 활성화에 기여할 수 있을 것으로 예상됨. 해당 연구 결과는 핵의학 의사, 신경과 및 정신과 임상 의사들에게 관심을 끌 수 있는 연구로 보임.

    2019-03-14 14:11:47

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