핵의학

본문글자크기
  • [Eur Radiol.] Correlation between the availability of dopamine transporter and olfactory function in healthy subjects.

    부산대 / 박경준, 김성장*

  • 출처
    Eur Radiol.
  • 등재일
    2018 Apr
  • 저널이슈번호
    28(4):1756-1760. doi: 10.1007/s00330-017-5147-7. Epub 2017 Nov 21.
  • 내용

    바로가기  >

    Abstract
    OBJECTIVES:
    Olfactory dysfunction in Parkinson's disease is usually prodromal to other symptoms. In this study, we aimed to explore the association of olfactory function with the availabilities of striatal dopamine transporter (DAT) in healthy subjects.

    METHODS:
    Data used in the preparation of this article were obtained from Parkinson's Progression Markers Initiative database ( www.ppmi-info.org/data ). The study population consisted of healthy controls with screening 123I-FP-CIT single photon emission tomography (SPECT). University of Pennsylvania Smell Identification Test (UPSIT) was assessed to evaluate the olfactory function.

    RESULTS:
    Totally, 181 healthy subjects (117 male, 64 female) with 123I-FP-CIT SPECT data were included in this study. Specific binding ratios (SBRs) of the caudate nucleus (rho = -0.4217, p < 0.0001), putamen (rho = -0.2292, p = 0.0019), and striatum (rho=-0.3425, p < 0.0001) showed a reduction with ageing. SBRs of the caudate nucleus, putamen, and striatum were positively correlated with UPSIT (rho = 0.3716, p < 0.0001; rho = 0.3655, p < 0.0001; rho = 0.3880, p < 0.0001). After controlling for age by partial correlation, SBRs of the caudate nucleus, putamen, and striatum showed an influence on UPSIT (rho = 0.3288, p < 0.0001; rho = 0.3374, p < 0.0001; rho = 0.3511, p < 0.0001).

    CONCLUSION:
    Olfactory function is associated with the availability of striatal DAT independent of age in healthy subjects.

    KEY POINTS:
    • Olfactory dysfunction in Parkinson's disease is prodromal to other symptoms. • The availability of dopamine transporter showed a reduction with ageing. • Olfactory function is associated with the availability of dopamine transporter.

     


    Author information

    Pak K1, Kim K1, Lee MJ2, Lee JM3, Kim BS4, Kim SJ5, Kim IJ1.
    1
    Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
    2
    Department of Neurology and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
    3
    Department of Neurosurgery and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
    4
    Department of Nuclear Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
    5
    Department of Nuclear Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea. growthkim@daum.net.

     

  • 키워드
    Brain; Dopamine plasma membrane transport proteins; Nuclear medicine; Smell; Tomography, emission computed, single photon
  • 편집위원

    FP CIT SPECT로 평가된 striatal DAT availability와 olfactory function의 상관성을 찾아낸 연구로 신경학 의사와 임상 핵의학자에게 유용한 정보를 제공할 것으로 생각됨. 또한 연구자가 소속된 기관에서 얻어진 자료가 아닌 일반에 공개된 자료를 이용한 것으로 소규모기관에 소속된 많은 임상 핵의학자에게 좋은 영향을 줄 것임.

    2018-05-10 10:17:55

  • 편집위원2

    도파민 운반체 영상을 이용해 MCI 등의 조기 발견을 목적으로 하는 경우 최근의 추세인 후각 기능 상실, GI trouble 등을 접목한 점이 임상에 적용가능성이 있다고 판단됨.

    2018-05-10 10:21:53

  • 덧글달기
    덧글달기
       IP : 44.211.116.163

    등록