가톨릭의대 / 성필수, 유이령*, 배시현*
Abstract
PURPOSE:
Sorafenib, an oral multikinase inhibitor, is a recommended treatment option available for patients with Barcelona Clinic Liver Cancer (BCLC)-C stage hepatocellular carcinoma (HCC). This study aimed to evaluate the performance of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) for predicting tumour progression during sorafenib treatment.
METHODS:
We formed a retrospective cohort comprising patients treated with sorafenib for at least 30 days and undergoing 18F-FDG PET/CT within 1 month before treatment. For statistical analyses, the tumour-to-liver standardised uptake value (SUV) ratio (TLR) of the most hypermetabolic lesion was measured.
RESULTS:
Among a total of 35 patients, two obtained partial remission, and 11 showed stable disease after the first response evaluation. Patients with a TLR ≥ 2.9 (n = 17) had a median overall survival (OS) of 3.7 months after sorafenib treatment, whereas patients with a TLR < 2.9 (n = 18) had median OS of 12.2 months (P < 0.001), although the disease control rate was not significantly different between the two groups. Pretreatment TLR ≥ 2.9 (hazard ratio [HR] = 6.318, P = 0.002) and Child-Pugh class B (HR = 4.316, P = 0.044) were poor prognostic factors for OS, and a TLR ≥ 2.9 (HR = 2.911, P = 0.024) was the only poor prognostic factor for progression-free survival in a multivariate analysis.
CONCLUSION:
Pretreatment tumour metabolic activity assessed by 18F-FDG PET is an independent prognostic factor for survival in patientswith BCLC-C stage HCC receiving sorafenib monotherapy, although it may not predict tumour response to the treatment.
KEYWORDS:
18F–FDG pet; Prognosis; Sorafenib; Time to progression; Tumour response
Author information
Sung PS1, Park HL2, Yang K1, Hwang S1, Song MJ1, Jang JW1, Choi JY1, Yoon SK1, Yoo IR3, Bae SH4.
1 Division of Hepatology, Department of Internal Medicine, The Catholic University Liver Research Center, College of Medicine, The Catholic University of Korea, #505 Banpo-dong, Seocho-gu, Seoul, 06591, South Korea.
2 Division of Nuclear Medicine, Department of Radiology, College of Medicine, The Catholic University of Korea, #505 Banpo-dong, Seocho-gu, Seoul, 06591, South Korea.
3 Division of Nuclear Medicine, Department of Radiology, College of Medicine, The Catholic University of Korea, #505 Banpo-dong, Seocho-gu, Seoul, 06591, South Korea. iryoo@catholic.ac.kr.
4 Division of Hepatology, Department of Internal Medicine, The Catholic University Liver Research Center, College of Medicine, The Catholic University of Korea, #505 Banpo-dong, Seocho-gu, Seoul, 06591, South Korea. baesh@catholic.ac.kr.
편집위원
Sorafenib 치료를 시행받은 간세포암에서 FDG PET으로 측정한 종양 대 간 SUV비 (TLR)가 예후를 예측 할 수 있음을 보여준 임상연구 결과임. 소화기 내과의사와 핵의학자에게 FDG PET의 간세포암에서의 유용성을 느끼게 해주는 논문으로 생각됨.
2018-04-17 10:57:51
편집위원2
이전 PET/MRI를 이용한 sorafenib 사용 HCC 환자에 대한 연구를 진행한 적이 있었는데 최종 결과가 아직 나오지 않은 상태에서 궁금했던 예후인자에 대한 내용이 포함되어 있어 흥미롭습니다.
2018-04-17 11:04:20