바로가기  >

Abstract

Off-target binding in the basal ganglia is commonly observed in the 18F-AV-1451 PET studies of the elderly. We sought to investigate the relationship between this phenomenon in  the basal ganglia and iron accumulation using iron-sensitive R2* MRI. 

Methods: 

Fifty-nine healthy controls and 61 patients with Alzheimer disease and mild cognitive impairment underwent 18F-AV-1451 PET and R2* MRI studies. A correlation analysis was performed for age, 18F-AV-1451 binding, and R2* values. 

Results: 

There was an age-related increase in both 18F-AV-1451 bindingin the basal ganglia and R2* values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. 18F-AV-1451 binding in the basal ganglia increased with R2* values.

Conclusion: 

Off-target18F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association.

Author information

Choi JY1,2, Cho H3, Ahn SJ4, Lee JH1, Ryu YH5, Lee MS3, Lyoo CH6.

1 Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
2 Division of Rhode Island-Convergence Research, Korea Institute Radiological and Medical Sciences, Seoul, Republic of Korea.
3 Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; and.
4 Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
5 Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea lyoochel@yuhs.ac ryuyh@yuhs.ac.
6 Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea; and lyoochel@yuhs.ac ryuyh@yuhs.ac.