글로벌 연구동향
방사선종양학
- 2023년 11월호
[J Clin Neurosci .] CyberKnife based fractionated stereotactic radiotherapy as an upfront treatment for cerebral arteriovenous malformation인하의대 / 이정심*, 박현선*
- 출처
- J Clin Neurosci .
- 등재일
- 2023 Sep 25:117:40-45.
- 저널이슈번호
- 내용
Abstract
Background: To explore the therapeutic outcomes of CyberKnife based fractionated stereotactic radiotherapy (CKFRT) for patients with cerebral arteriovenous malformations (AVM).Methods: Between January 2008 and October 2020, 45 patients underwent CKFRT for cerebral AVMs as a first treatment. The delineation of AVM targets included AVM nidus. The mean target volume was 4.07 cm3, and 9 lesions (20%) were larger than 10.0 cm3. The mean marginal dose was 24 Gy (range, 20-35 Gy). CKFRT was delivered in median 3 fractions (range, 2 ∼ 5 fractions). AVM obliteration following CKFRT was confirmed by magnetic resonance imaging or angiography.
Results: During a median follow-up of 47 (5-148) months, complete obliteration and partial obliteration of AVM after CKFRT were obtained in 23 (51%) and 13 (29%) patients, respectively. Median time to complete obliteration was 39 (15-63) months. The cumulative probability of complete obliteration rate at 3 years was 47%. Complete obliteration rate of AVM was associated with Radiosurgery-based AVM score, which was consisted of AVM volume, patients age, and AVM location. One (2%) patient had hemorrhage during the follow-up period.
Conclusions: CKFRT is an effective primary treatment for patients with cerebral AVMs with a low hemorrhage risk.
Affiliations
Jeongshim Lee 1, Woo Chul Kim 2, Hun Jung Kim 2, Hyeonseon Park 3
1Department of Radiation Oncology, Inha University Hospital, Inha University School of Medicine, Incheon, South Korea. Electronic address: jshimlee@inha.ac.kr.
2Department of Radiation Oncology, Inha University Hospital, Inha University School of Medicine, Incheon, South Korea.
3Department of Neurosurgery, Inha University Hospital, Inha University School of Medicine, Incheon, South Korea. Electronic address: hspark@inha.ac.kr.
- 키워드
- Cerebral arteriovenous malformations; CyberKnife; Obliteration; Stereotactic radiotherapy.
- 덧글달기
- 이전글 [Diagnostics (Basel) .] Evaluating the Necessity of Adaptive RT and the Role of Deformable Image Registration in Lung Cancer with Different Pathologic Classifications
- 다음글 [Sci Rep .] Effect of whole-brain radiotherapy with platinum-based chemotherapy in non-small cell lung cancer patients with multiple metastases including brain metastases