글로벌 연구동향
방사선종양학
- 2022년 08월호
[Korean J Gastroenterol.] Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Hepatocellular Carcinoma Treated with Stereotactic Body Radiotherapy순천향의대 / 박영희, 장아람*
- 출처
- Korean J Gastroenterol.
- 등재일
- 2022 Jun 25
- 저널이슈번호
- 79(6):252-259. doi: 10.4166/kjg.2022.021.
- 내용
Abstract
Purpose: To investigate the prognostic value of the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in patients with hepatocellular carcinoma (HCC) treated with stereotactic body radiotherapy (SBRT).Methods: The medical records of HCC patients treated with SBRT between 2008 and 2019 were reviewed retrospectively. The NLR and PLR were calculated from the serum complete blood count before and after SBRT, and the prognostic values of the NLR and PLR for the treatment outcomes were evaluated.
Results: Thirty-nine patients with 49 HCC lesions were included. After a median follow-up of 26.8 months (range, 8.4-80.0 months), three-year local control, overall survival (OS), and progression-free survival (PFS) rate were 97.4%, 78.3%, and 35.2%, respectively. Both NLR and PLR increased significantly after SBRT and decreased slowly to the pre-SBRT value at 6 months. Univariable analysis showed that gross tumor volume (GTV) >14 cc, post-SBRT PLR >90, and PLR change >30 were associated with a poorer OS (p=0.002, p=0.011, and p=0.001, respectively), and the PLR change was significant in multivariable analysis (hazard ratio [HR], 10.09; 95% CI, 1.15-88.40; p=0.037). For PFS, GTV >14 cc, post-SBRT NLR >2.5 and post-SBRT PLR >90 were predictive of a poorer PFS in univariable analysis (p=0.011, p=0.004 and p=0.041, respectively) and only post-SBRT NLR >2.5 remained significant in multivariable analysis (HR, 2.44; 95% CI, 1.03-5.76; p=0.042, respectively).
Conclusions: The NLR and PLR increased transiently after SBRT, and the post-SBRT NLR and PLR were associated with the clinical outcomes of HCC patients.
Affiliations
Younghee Park 1 , Ah Ram Chang 2
1 Department of Radiation Oncology, Ewha Womans University Seoul Hospital, Seoul, Korea.
2 Department of Radiation Oncology, Soonchunhyang University Seoul Hospital, Seoul, Korea.
- 키워드
- Carcinoma, hepatocellular; Neutrophil to lymphocyte ratio; Platelet to lymphocyte ratio; Prognosis.
- 덧글달기
편집위원
간암으로 SBRT를 시행받은 환자에서 치료 후 NLR 및 PLR이 예후에 미치는 영향을 분석한 논문
덧글달기닫기2022-08-02 11:42:37
등록