글로벌 연구동향
방사선종양학
- 2016년 01월호
[Radiat Oncol] Definitive radiotherapy alone over 60 Gy for patients unfit for combined treatment to stage II-III non-small cell lung cancer: retrospective analysis울산의대 / 주지현, 김수산, 정유리, 정성윤, 최원식, 송시열*, 최은경*
- 출처
- Radiat Oncol
- 등재일
- 2015 Dec 3
- 저널이슈번호
- 10(1):250. doi: 10.1186/s13014-015-0560-z.
- 내용
Abstract
BACKGROUND:
Elderly patients with non-small cell lung cancer (NSCLC) are frequently treated with radiation therapy (RT) alone, due to poor performance status or underlying disease. We investigated the effectiveness of RT over 60 Gy administered alone to NSCLC patients who were unfit or rejecting for combination treatment.
METHODS AND MATERIALS:
From April 2002 to July 2010, 83 patients with stage II-III NSCLC, aged over 60 years, treated by RT alone with a curative aim were analyzed. Radiation was targeted to the primary tumor and clinically involved lymph nodes. A total dose of 66 Gy in 30 fractions (2.2 Gy/fraction) was delivered once daily (5 fractions weekly). One month after completing RT, initial tumor responses were evaluated.
RESULTS:
Median age of patients was 73 years (range, 60 - 82 years). The median survival time was 18.6 months (range, 2-135). The actuarial overall survival rates at 2 and 3 years were 39 % and 23 %, and cause-specific survival rate at 2 and 3 years were 57 % and 47 %, respectively. When primary tumor was controlled, the 2- and 3-year CSS were 56 % and 45 %, but 32 % and 23 % in those patients with local failure, respectively (P = 0.017). Additionally, the local control rate was associated with the initial tumor response (P = 0.01). No patient experienced grade 4+ toxicity.
CONCLUSIONS:
For stage II-III NSCLC patients aged over 60 years and unfit or rejecting for combination treatment, RT alone showed promising result. Long-term disease control can be expected if an early tumor response to radiation is achieved, which could result in improved overall survival rates.
Author information
Joo JH1, Song SY2,3, Kim SS4, Jeong Y5, Jeong SY6, Choi W7, Choi EK8,9.
1 Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-Gu, 138-736, Seoul, Korea. hi_juji@daum.net.
2 Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-Gu, 138-736, Seoul, Korea. siyeol.song@gmail.com.
3I nstitute for Innovative Cancer Research, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. siyeol.song@gmail.com.
4 Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-Gu, 138-736, Seoul, Korea. watermountain@hanmail.net.
5 Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-Gu, 138-736, Seoul, Korea. jyr2646@naver.com.
6I nstitute for Innovative Cancer Research, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. syj@amc.seoul.kr.
7 Department of Radiation Oncology, Gangeung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea. 16choi@hanmail.net.
8 Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-Gu, 138-736, Seoul, Korea. ekchoi@amc.seoul.kr.
9 Institute for Innovative Cancer Research, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ekchoi@amc.seoul.kr.
- 덧글달기
- 이전글 [PLoS One] Radiation Inhibits Interleukin-12 Production via Inhibition of C-Rel through the Interleukin-6/ Signal Transducer and Activator of Transcription 3 Signaling Pathway in Dendritic Cells.
- 다음글 [Int J Radiat Oncol Biol Phys] Concurrent Chemoradiation Therapy Followed by Consolidation Chemotherapy for Localized Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type.