방사선종양학

본문글자크기
  • [J Gynecol Oncol.] Prognostic value of post-treatment ¹⁸F-fluorodeoxyglucose positron emission tomography in uterine cervical cancer patients treated with radiotherapy: a systematic review and meta-analysis.

    울산의대 / 김연주, 김영석*

  • 출처
    J Gynecol Oncol.
  • 등재일
    2019 Sep
  • 저널이슈번호
    30(5):e66. doi: 10.3802/jgo.2019.30.e66.
  • 내용

    바로가기  >

    Abstract
    OBJECTIVES:
    To perform a systematic review and meta-analysis of the prognostic value of post-treatment ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) in uterine cervical cancer patients treated with radiotherapy (RT) with or without chemotherapy.

    METHODS:
    PubMed and Embase databases were searched up to July 22, 2018, for studies which evaluated the response outcomes of ¹⁸F-FDG PET following RT, and their prognostic significance in uterine cervical cancer was assessed with overall survival (OS) or progression-free survival (PFS) as endpoints. Hazard ratios (HRs) were meta-analytically pooled using the random-effects model.

    RESULTS:
    Eleven studies with 12 patient cohorts including 1,104 patients were included. For a quantitative synthesis of OS, 7 cohorts were included. Two cohorts which reported disease-specific survival instead of OS were also included with flexibility. Pooled HR of complete metabolic response (CMR) compared to partial metabolic response (PMR) was 0.19 (95% confidence interval [CI]=0.11-0.31). Pooled HR of CMR compared to progressive metabolic disease (PMD) was more evident at 0.07 (95% CI=0.04-0.12), and that of CMR compared to both PMR and PMD was 0.20 (95% CI=0.12-0.34). Quantitative synthesis for PFS was performed with a total of 8 cohorts. Pooled HR of CMR was 0.17 (95% CI=0.10-0.29) compared to PMR, 0.02 (95% CI=0.01-0.06) compared to PMD and 0.12 (95% CI=0.07-0.19) compared to both PMR and PMD.

    CONCLUSION:
    Response results of post-RT ¹⁸F-FDG PET were significant prognostic factors in patients with uterine cervical cancer, and ¹⁸F-FDG PET could be a reasonable follow-up imaging modality.

     


    Author information

    Kim YJ1, Han S2, Kim YS3, Nam JH4.
    1
    Department of Radiation Oncology, Kangwon National University Hospital, Chuncheon, Korea.
    2
    Department of Nuclear Medicine, The Armed Forces Daejeon Hospital, Daejeon, Korea.
    3
    Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ysk@amc.seoul.kr.
    4
    Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

  • 키워드
    Positron Emission Tomography; Radiotherapy; Survival; Uterine Cervical Neoplasms
  • 덧글달기
    덧글달기
       IP : 174.129.140.206

    등록